General Surgery »  Faculty »  Division Chief »  Hobart W. Harris, M.D., M.P.H.

Hobart W. Harris, M.D., M.P.H.

Professor and Chief, Division of General Surgery
Vice-Chair, Department of Surgery
J. Engelbert Dunphy Endowed Chair in Surgery

Contact Information

513 Parnassus Avenue
San Francisco, California 94143-0104
Clinical Telephone: (415) 353-2161
New Patient Coordinator Telephone: (415) 353-2804
Academic Telephone: (415) 514-3891
Fax: (415) 476-0164


  • 1975-1979 Harvard College, Cambridge, MA       A.B. Biology
  • 1979-1983 Harvard Medical School, Boston, MA     M.D. Medicine
  • 1983-1984 Harvard School of Public Health, Boston, MA M.P.H. General Studies


  • 1984-1985 University of California, San Francisco Intern Surgery
  • 1985-1993 University of California, San Francisco Resident Surgery


  • 07/1993-12/1993 University of Hong Kong, Queen Mary Hospital, Hong Kong, P.R.C. Hepatobiliary Surgery
  • 02/2005-07/2005 University of Louisville, Louisville, KY ERCP

Board Certifications

  • American Board of Surgery, 1994

Clinical Expertise

  • Acute Pancreatitis
  • Bile Duct Injuries
  • Cancer Surgery
  • Chronic Pancreatitis
  • Gall Bladder Disease
  • Gastrointestinal Cancer
  • Gastrointestinal Surgery
  • Intra-abdominal Sepsis
  • Pancreas Surgery
  • Pancreatic Cancer
  • Soft Tissue Infections


Dr. Hobart W. Harris, Chief of General Surgery at the UCSF Medical Center, is an expert in treating surgical infections, diseases of the pancreas and biliary system and abdominal wall hernias, including pancreas, gallbladder and bile duct cancer, acute and chronic pancreatitis, islet autotransplantation for chronic pancreatitis, complex gallstone disease, intra-abdominal sepsis, serious infections of the skin and soft tissue, and enterocutaneous fistulas. He treats patients with complicated and often life-threatening conditions through the Complex Abdominal Surgery Program. Dr. Harris is also a pioneer and leader in the management and repair of complex ventral (incisional) hernias. Specifically, he is an expert at repairing gigantic ventral hernias, where closure of the defect and reconstructing the abdominal wall requires advanced techniques, such as progressive pneumoperiteum whereby the abdominal wall muscles are first stretched prior to repairing the hernia.

Dr. Harris earned his undergraduate, medical and public health degrees at Harvard University, before completing an internship and residency in general surgery at UCSF. After residency training, he completed a fellowship in Hepatobiliary Surgery at the University of Hong Kong, Queen Mary Hospital before joining the faculty at UCSF in 1994. Harris is a Fellow of the American College of Surgeons and is a member of numerous surgical and scientific societies including the American Surgical Association. Dr. Harris is Director of the Infection, Injury and Immunity LabHis research focuses on surgical infections, innate immunity and the management of complex ventral hernias.

Clinical Trials


Featured Publications

  1. Harris HW, Grunfeld C, Feingold KR and Rapp JH. Human VLDL and chylomicrons can protect against endotoxin-induced death in mice. J Clin Invest. 86: 696-702, 1990.
  2. Harris HW, Grunfeld C, Feingold KR, Read TE, Kane JP, Jones AL, Eichbaum EB, Bland GF and Rapp JH. Chylomicrons alter the fate of endotoxin, decreasing tumor necrosis factor release and preventing death. J Clin Invest. 91: 1028-1034, 1993.
  3. Harris HW, Johnson JA, Wigmore SJ. Endogenous lipoproteins impact the response to endotoxin in humans. Crit Care Med. 30: 23-31, Jan/2002.
  4. Kasravi FB, Welch WJ, Peters-Lideu CA, Weisgraber KH, Harris HW. Induction of cytokine tolerance in rodent hepatocytes by chylomicron-bound LPS is low-density lipoprotein receptor dependent. Shock. 19: 157-62, Feb/2003.
  5. Spitzer AL, Barcia AM, Schell MT, Barber A, Norman J, Grendell J, Harris HW. Applying Ockham's razor to pancreatitis prognostication: a four-variable predictive model. Ann Surg. 243: 380-8, Mar/2006.