General Surgery »  Faculty »  SFGH General Surgery »  Mitchell J. Cohen, M.D.

Mitchell J. Cohen, M.D.

Professor of Surgery
Division of General Surgery
Associate Trauma Medical Director, SFGH
Director of Trauma Research, SFGH
Director of Acute Care Research, San Francisco Injury Center 

Contact Information

Campus Box 0807
San Francisco, CA 94143-0807
(415) 206-8673 Appointments
(415) 206-4623 Office
(415) 206-5484 Fax

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  • Brandeis University, Waltham, Massachusetts, B.A., Politics, 1991
  • Mount Sinai School of Medicine, New York, New York, M.D., 1997
  • Rush University/Cook County Integrated Surgical Residency, Chicago, Illinois, 1997-2004
  • Loyola University Medical Center,Department of Surgery, Burn and Shock Trauma Institute, Maywood, Illinois,1999-2001
  • UCSF, Trauma and Critical Care Fellowships, San Francisco General Hospital, San Francisco, California, 2004-2006
  • American Board of Surgery, 2005
  • American Board of Surgery, Surgical Critical Care, 2005
  • Critical Care Surgery
  • General Surgery
  • Trauma Surgery

Dr. Mitchell Cohen, Assistant Professor of Surgery in Residence, joined the faculty at UCSF-SFGH in July 2006. Dr. Cohen is a Board-certified general surgeon with an additional board certification in Surgical Critical Care.

Dr. Cohen received his undergraduate degree from Brandeis University and his medical degree at the Mount Sinai School of Medicine.  He then completed his Residency at Rush University/Cook County Integrated in 1994.  He then completed a Research Fellowship at Loyola University Medical Center in the Department of Surgery, Burn and Shock Trauma Institute in 2001 and a Fellowship in Trauma and Critical Care UCSF-SFGH from 2004-2006.

Dr. Cohen has an active basic science research lab where he studies coagulation and inflammation perturbations after trauma. In addition he is actively involved in the CDC San Francisco Injury Center with projects related to inflammatory lung injury and monitoring of resuscitation and coagulation after injury.  Dr. Cohen was recently awarded a fellowship award in Hemostasis and Resuscitation from the American Association for the Surgery of Trauma.  Along with his clinical and basic science translational research, Dr. Cohen has a keen interest in in silico and informatic modeling of biological systems and patient physiology. These interests have led to work with collaborators at UCSF and UC Berkeley as well as the Intel Corporation.

Dr. Cohen currently is the Acute Care Director for the CDC San Francisco Injury Center. He continues to have a busy clinical practice and is one of the most productive research physicians at the University of California, San Francisco, San Francisco General Hospital.

Dr. Cohen's research centers on perturbations of coagulation after trauma. Specifically his lab continues to examine the mechanism of traumatic coagulopathy and complement dependent activation of the protein C system after trauma. Concurrently patient samples are collected to further examine traumatic coagulopathy and the activation of protein C after trauma. Over the past year his research group has published 5 manuscripts with two additional in review. In October, he submitted an NIH K08 application centered around in vivo, in vitro and in silico approaches to traumatic coagulopathy. Natasha Bir, MD has recently joined Dr. Cohen's  lab and has begun an ambitious project looking at the effect of protein C on endothelial permeability.

In addition to the basic science work, Dr. Cohen continues work on the application of complex systems approaches to modeling coagulation, inflammation and high throughput physiologic data from severely injured patients.  He contributes to and receives funding from the 2007-2009 UC Discovery Grant Grant No: GCP06 10226. This grant seeks to apply novel bioinformatics techniques to severely injured ICU patients.

Dr. Cohen has contributed to and is partially funded by the National Center for Injury Prevention and Control Grant No: R49/CCR903697-07. As part of the CDC San Francisco Injury Center he is overseeing acute care research. Specifically his work centers on the application of new monitoring technologies to detect the efficacy of our resuscitation conduct. In this role, he oversees several residents and medical students.

ResidentYearsGrant or Funding Source
Lucy Kornblith, M.D. 2012- Trauma Training Fellow
Matt Kutcher, M.D. 2010-2012 T32 Trauma Training Fellow
Lisa Marie Brown, M.D. 2008-2009 T32 Trauma Training Fellow
Most recent publications from a total of 120
  1. Hendrickson CM, Howard BM, Kornblith LZ, Conroy AS, Nelson MF, Zhuo H, Liu KD, Manley GT, Matthay MA, Calfee CS, Cohen MJ. The acute respiratory distress syndrome following isolated severe traumatic brain injury. J Trauma Acute Care Surg. 2016 Jun; 80(6):989-97. View in PubMed
  2. Howard BM, Kornblith LZ, Cheung CK, Kutcher ME, Miyazawa BY, Vilardi RF, Cohen MJ. Inducing Acute Traumatic Coagulopathy In Vitro: The Effects of Activated Protein C on Healthy Human Whole Blood. PLoS One. 2016; 11(3):e0150930. View in PubMed
  3. Baimukanova G, Miyazawa B, Potter DR, Muench MO, Bruhn R, Gibb SL, Spinella PC, Cap AP, Cohen MJ, Pati S. Platelets regulate vascular endothelial stability: assessing the storage lesion and donor variability of apheresis platelets. Transfusion. 2016 Mar; 56 Suppl 1:S65-75. View in PubMed
  4. Callcut RA, Cripps MW, Nelson MF, Conroy AS, Robinson BB, Cohen MJ. The Massive Transfusion Score as a decision aid for resuscitation: Learning when to turn the massive transfusion protocol on and off. J Trauma Acute Care Surg. 2016 Mar; 80(3):450-6. View in PubMed
  5. Rowell SE, Fair KA, Barbosa RR, Watters JM, Bulger EM, Holcomb JB, Cohen MJ, Rahbar MH, Fox EE, Schreiber MA. The Impact of Pre-Hospital Administration of Lactated Ringer's Solution versus Normal Saline in Patients with Traumatic Brain Injury. J Neurotrauma. 2016 Jun 1; 33(11):1054-9. View in PubMed
  6. Callcut RA, Wakam G, Conroy AS, Kornblith LZ, Howard BM, Campion EM, Nelson MF, Mell MW, Cohen MJ. Discovering the truth about life after discharge: Long-term trauma-related mortality. J Trauma Acute Care Surg. 2016 Feb; 80(2):210-7. View in PubMed
  7. Campion EM, Juillard C, Knudson MM, Dicker R, Cohen MJ, Mackersie R, Campbell AR, Callcut RA. Reconsidering the Resources Needed for Multiple Casualty Events: Lessons Learned from the Crash of Asiana Airlines Flight 214. JAMA Surg. 2016 Jan 13; 1-6. View in PubMed
  8. Howard BM, Kornblith LZ, Conroy AS, Burlew CC, Wagenaar AE, Chouliaras K, Hill JR, Carrick MM, Mallory GR, Watkins JR, Truitt MS, Ciesla DJ, Davis JA, Vail CJ, Kemp Bohan PM, Nelson MF, Callcut RA, Cohen MJ. The found down patient: A Western Trauma Association multicenter study. J Trauma Acute Care Surg. 2015 Dec; 79(6):976-82. View in PubMed
  9. Howard BM, Miyazawa BY, Dong W, Cedron WJ, Vilardi RF, Ruf W, Cohen MJ. The tissue factor pathway mediates both activation of coagulation and coagulopathy after injury. J Trauma Acute Care Surg. 2015 Dec; 79(6):1009-14. View in PubMed
  10. Moren AM, Hamptom D, Diggs B, Kiraly L, Fox EE, Holcomb JB, Rahbar MH, Brasel KJ, Cohen MJ, Bulger EM, Schreiber MA. Recursive partitioning identifies greater than 4 U of packed red blood cells per hour as an improved massive transfusion definition. J Trauma Acute Care Surg. 2015 Dec; 79(6):920-4. View in PubMed
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